While I kinda doubt it I really wanna see 
walk in and start wrecking stuff. You thought Graves was brutal? Imagine Naut fighting against Gangplanks entire ship! Maybe even squish a couple prate thugs with his anchor. That and we may finally see what he's thinking under that suit.
Hoping, yes. The thing actually happening, highly unlikely. If not, we might see something about him during the Harrowing season.
I would like to see Nautilus, but let's be real. The guy is wandering around somewhere deep under the Guardian Sea. If he were to find dry land anywhere, Naut's lore would halfway resolve itself. He's not gonna be anywhere in this event, sadly.
I'd rather see him in an event better-suited to who he is and justifying WITH GOOD REASON why he's there.
Also I have to point out, the Bilgewater event pointed out that Runeterra has 12 seas...we only knew 2 before this information, keep that in mind for future reasons. It may have something linked with our suited giant.
If they do more Bilgewater Lore I want a cinematic with Nautilus and all the Bilgewater Champs fighting an enormous sea monster. T'would be perfect for the Harrowing.
Or hell, Nautilus can BE the sea monster.
