Sadly, with the current way the yordles are coming - they are basically fairies that barely even interact with humans, also being nearly timeless (or maybe even timeless), so I highly doubt that. Especially since they can't even be recognized as Yordles by humans.
I liked the previous iteration of yordles WAY more. Basically underdogs of runeterra, a race that is smaller, doesn't have exceptional magic powers and, most importantly, made of flesh and blood (also fur). And even though they were underdogs they were still keeping up, mostly thanks to their wits.
Interaction was pretty much constant, with multiple Yordles living (and being recognized by humans) in major human cities (Poppy was the Ambassador of Demacia, while Heimer and Ziggs were living in Piltover to my knowledge (also, all the unnamed Yordles that went to Yordle academy - which was in piltover) and his former students spoke highly of Heimer. From Rumble lore:
He only intended to get a good look at the humans, but four hours and several choice words later, he returned home bruised and bloodied with an earful about how he was an embarrassment to "enlightened" yordles like Heimerdinger.
So, I imagine that yes - there were Yordle x Human couples (even though I imagine a decent amount of both humans and yordles would shun such couples).
...
I dunno, new Yordles... I just don't get it. While I loved a lot of changes to the lore after the retcon (Bilgewater, DAMN that was good now Zaun is also pretty damn good, Shurima was alright (Xerath seems very undeveloped - he's just a villain, but others ended up nicely)). I just can't relate to completely mythical creatures that the Yordles have become.