Ryze: Call of Power Theory
Alright so in The new Ryze cinematic, after he leaves we see 5 "chambers" for runes, but only four of them are filled, leaving one empty. So far Ryze has had 4 reworks, I think each of these runes symbolize one of them, and the last one is a rework to come, his final one (or something I guess). According to one of his previous lores "Ryze is no longer just a mage - he has become a creature of magic itself" shows that he is tied to the magic, or the runes very deeply, and one of his voice lines say: "When I've found them all, I'll fade away." This wouldn't make sense though, Ryze's lore is so prominent in the LOL universe, one could say he's the "Main Character", so I think when he finds the last rune, he will be reworked, but rather returned to his human form (like we dont even need to update his skill set just literally change his base skin with the young Ryze skin, and make it Runic Ryze or something like that and update the rest of his skins to match his young Ryze coloration) so I think that instead of fading away entirely, his magic form will fade, returning him to a human. (Just my thoughts personally)