BEES!
I think it would be cool to make a beekeeper skin for one or more of the following champions: Singed, Malzahar, Teemo, Heimerdinger, Elise. As is normal for themed skins, they would have different particle effects.
Malzahar Passive: Summon a bee every fourth ability rather than a voidling Q: Artificial bee hives make up either end of the abillity and bees trailing honey move from one to the other W: Honey pool with honeycomb making up the border E: Space aids is now space bees R: Stream of honey or bees or something. Maybe a mixture. Have fun with it.
Singed Q: Trail of bees W: Honey pool = sticky
Teemo Q: Fires a single bee which buzzes while flying and makes a Donkey Kong Country style bee death sound on impact R: Place bee hives.
Heimerdinger Q: Place bee themed turrets which fire bee stingers/honey globs normally and full fledged bees as the charged shot. W: Rocket propelled bees. E: Smoke grenade theme (same effect as usual, just different particle since smoke pacifies bees). R: Have fun.
Queen Bee Elise Passive: Spiderlings are now bees Human form: bee keeper outfit W: Bee bomb E: Sticky honey Spider form: big waddling bee E: Fly up rather than rappel
Or, if you really want to, go whole hog and make a Queen Bee champion (kind of like the Elise skin I mentioned). The champ could be a big waddling bee which takes flight when its speed reaches a certain threshold (kind of like Thresh), maybe focusing on temporary terrain creation (honeycombs or honey field for slows) and suicidal summons, possibly in the same vein as Elise or Maoki, but also possibly as a rotating defense/offense a la Diana or Ahri. Maybe have an AOE CC of some kind for her ultimate as she buzzes/kicks up wind with her wings. And, of course, she would need some sort of stinger based ability, possibly melee or maybe firing the stinger, which I imagine would poison the enemy. Using the above, I would imagine Q=Stinger, W=Honeycomb wall, E=Suicide minion, R=Buzz buzz. As written with a melee based playstyle, I imagine her strategy would revolve around using her created terrain to corner enemies and sting them to death while using suicide summons to poke them down or defend (if it offered some sort of healing or shield). As a ranged champion, she would be more focused on keeping enemies at bay with created terrain rather than trapping them and poking enemies down with bees and stingers, possibly with an AOE knockback or fear as her ult.
Ultimately it's your game, so use these or not as you please. I just thought these were fun ideas, and this is the place to vent those.