As much as I'd love to see skins related to Greek mythology, anything simply based off a God or Goddess would be way too similar to Smite and would probably just come across as a rip-off, which is a shame because an Aphrodite-inspired Janna skin would be perfection! The Mythic series would be a good choice to expand on if Riot wanted to make mythology (specifically Greek) based skins without necessarily "copying" Smite.
If I remember correctly, Pantheon is from Mount Targon which draws inspiration from Ancient Rome and Greece. It'd be neat to see Mount Targon expanded upon alongside a series of skins that correspond with that. I think that'd be a cool option! :)