I play Lol in a mac laptop, with no mouse... I point with the touch pad, the right and up keys for moving and attacking and the normal QWER for abilities. I have to stop moving when using abilities, so I just click with the right key where I want to go and then use the abilities.
First this was really hard and I kept moving to the enemy while trying to cast spells but now it's just fine, I'm used to it and I can't play with a mouse.
I play League on a tablet.
Without a mouse.
I play league with trackpad no mouse its impossible with mouse lol