Unbeatable URF Lanes?

What're the champions or champion combinations in a lane that make you want to Alt-F4 when you see them in URF?

are probably my top 3 most hated champions to face in URF. Jayce because his Shock Blast spam just HITS. SO. HARD. Karthus because Q vomit and 20 second global damage ulti turns the game into backing at 50% HP rather than 20%. And Maokai because he will just never die. Ever. Late game Sap Magic CD just makes it such an uphill battle to fight. I literally played a game of Maokai where Sejuani jumped on me while I was at like 200 HP, she had like 5k, and I healed to full (5k) in 2 procs and beat her to death under her own tower. This shit is bananas.

As far as a 2v2 lane combo that makes me want to kill myself, is absolutely the most AIDS inducing combo I've ever seen. They just non-stop all-in past level 3 and murder you.