I don't see why not
+
I don't care what are parents say, I'm in love with you Rek'sai!
happy clicking noises
Run away with me my love!
You mean that you destroyed my land just to catch my attention? How lovely!
Lovely screeches while eating one of his sand minions
http://i.imgur.com/gtK7JEE.png?noredirect
..........
x
http://media.tumblr.com/tumblr_m3ol7oiH8L1qdj7w9.gif
Can't see my lowest on my phone so I will go with my 3th and 4th
x
http://media.tumblr.com/tumblr_lukotsQyTL1qkv4zy.gif
+ 
http://1.bp.blogspot.com/-83Z6hZKo_tI/UX_KnC0l3iI/AAAAAAAACG8/x2-dt9X7ts0/s400/Confused-GIF[1].gif
+ 
: Fear the ocean's weight ( ͡° ͜ʖ ͡°)
: Suffering is magic ( ͡° ͜ʖ ͡°)
http://img.pandawhale.com/post-31731-Rudy-Misfits-gif-disgusted-Img-QceB.gif
So... Sona x Ashe?..
https://media.giphy.com/media/KYNywoibU1PQ4/giphy.gif Not shipping it but its alright.
Sadly I cant see my lowest 2 atm, on mobile :/
(Also upvoted for RWBY)
+
It took a thought as strange as this to make me feel bad about playing them now..
Also I knew you shipped Riven and Shyv but I didn't know you actually played her. HOW DO YOU PLAY HER D= I can't play her for jack squat. Like I don't get her purpose in the game due to her lack of CC and being easily kited by
+ 
ooh kinky :^)
+ 
0_o
+ 
0_o
+ 
FTFY
x
: So, you do chemistry?
: Yah?
: Oh, well I have a Solution to your problems
: Ready to run "What exactly?"
: From his pocket he pulls out a hair growth formula "This should help"
: taking it, he rubs it on his head and gets a full set of blond hair "Can you make more?"
x
http://s2.quickmeme.com/img/39/3921dfe14e67cf0f694b4c67e8646e123382b4f257a46c79aef71a079b0c902a.jpg
Make me a minion sandwich, b***h :)
x
uh.....
x 
"Who wants a piece of the champ?"
"Who wants a piece of this?"
Maybe because it's 2 in the morning here but your thread title makes no sense to me.
Really I think it's Simple What are your two Highest Mastery Champions and what are your two Lowest High rank Mastery Champions :P
I have to admit that 'lowest highest' being side by side in a sentence does make it very hard to understand it's meaning
highest

Lowest (that have actually been played)

mundo X voli and voli X ww
AWKWARD
x 
This actually makes some sense.
x 
My mind is going to some dark, dark places right now....
+
wat
+
I'm sure many boards members will approve. ( ͡° ͜ʖ ͡°)
and
+
Not really sure on that one. :P
Edit: I went highest with lowest and second highest with second lowest if high with high and low with low, it's Janna x Thresh, and Garen x Ahri
+
0.0
&
I'm getting 'My New Haircut' vibes from these two.
& 
One day Nasus will find a cure for insanity and seek out Renekton, only to find out Renekton has settled down, married Sejuani, and started a family of four...
Renekton will then offer Nasus a fur parka upon meeting again; Renekton has a lot of them because the Freljord is not conducive towards reptilian Ascended.
 + 
: Uhhh...
: What kind of blind date is this?
: GUY'S LOOK! YI AND DARIUS ARE ON A DATE
: I knew you loved him Darius~
: Oh god.
: I must be on shrooms!
 + 
: The light of Demacia will n-not falter..?
: I thought when they said a blind date, they mean't a woman who was also like me. I didn't think they mean't I wouldn't know who I'm dating.
: I didn't plan this either.
: Let's leave before Teemo calls us out like he called out Yi and Darius.
: Yeah.
: Wanna get grub at Burgot's? It's on me. (If I knew where my wallet was)
: Yeah sure. As FRIENDS though.
: I know. Jesus Christ, I'm gonna find that guy who put me on this date.
: (Just let me post this on leaguebook...) tic tic tic
... I don't think it would work due to the fact I only played DRAGONSLAYER pantheon for his mastery points..
https://gyazo.com/f891de971ff4986c623c04a9dbfb55c1.jpg
X
https://gyazo.com/018b375ff8f11095ccf88b6037b1c6b7.jpg
Somehow don't see them getting along too well..
Edit: oh almost forgot..
+ 
The only problem I have with this thread is that I still don't have mastery on most of the champions I own.
So, top two is still...
x 
So... How exactly are you going to pleasure me?
Maybe I should just hunt down Gangplank for you.
Sold! Just make sure I get to kill him myself.
Does it matter if he knows he's going to be killed?
Oh, right, your fear stuff. Yeah, definitely go ahead and do that. I want him to beg for me to release him from your nightmares.
I'm gonna enjoy this!
+
"So... do you like science?"
(Not counting champs I don't have any mastery on):
+
I.. I don't even know
I went based on if I have Champion points on a champion, since I don't own/play all of them.
Highest:
x
Nice botlane duo there.
Lowest:
x
Don't know if it would work out.
+
umm
+
kool
+
( ͡° ͜ʖ ͡°)
x 
No matter how you put it, male x male, male x genderbender, genderbender x genderbender, those two are going to go against it with a lot of metal. ( ͡° ͜ʖ ͡°)
x
The two supports I never got to love. I do believe they deserve each other, because they are horrible.
https://media.giphy.com/media/xTiQyDiep976jTwRcQ/giphy.gif
Prefer

In a bra and panties pillow fight. (With some making out in between)
x
._. .................
Ok.