LoL Anime: Annie Vs Riven: Animation

I don't see why they couldn't. It could be structured similar to the "Pokemon" anime, only in a sort of "reverse." Rather than be about a small set of characters meeting and capturing a large set of characters, it's about a large set (perhaps divided into groups) interacting. They could, alternatively, rather than releasing one temporal plot, do a series of short story episodes, like a 3 episode set about Garen and Darius' rivalry, a set of episodes about the Noxian charaters/history and how they related. They wouldn't even need to make it about SR or anything, it could just take place in Runeterra and be a large web of small character/plot arcs.

Rito! As a writer, I would be more than happy to help write these :P as if they'd ever consider me! haha