If League Of Legends become an anime
Whom would the main character be?
?
?
?
?
?
or maybe
[slayer-jinx-wink] ?
Whom would the main character be?
?
?
?
?
?
or maybe
[slayer-jinx-wink] ?

The most anime like characters in this game obviously
No one. It would be like Durarara.... I think that's the name.... where everyone is technically a main character, but no one actually is.
I dunno, with the Japanese obsession with cute things,
https://i.gyazo.com/950458ccffabc894b4c230b39e7931a4.png
I could legit see it being some school themed slice of life/comedy style show featuring all the yordles.
Any of those would make me want to drink bleach rather than watch that show.
I think
, because DEMACIA!!
I could see him as a main character in a super hero show
Sion.
Because screw anime protagonist stereotypes!!
Depends on the Genre:
Ecchi
Shonen
seinen
Feels 
could be nice, if the boards wouldn't shit over Riot for picking a champion they QQ nonstop about.
pai pls
obviously
I feel like it would be done like Durarara, where there are several main characters who interact with each others stories.
or
, they are the posterboys of league.
https://media.giphy.com/media/3oz8xLVqgtwBud2wpO/200w.gif
Need I say more?
It'd need to be one of the old guard, who have the most established lore presence, serving as main character. I propose

Why not just make it like "Lu's Time" (the Chinese anime)?
A team of outcasts try to climb up the ladder to live their dreams of being e-sports pros.
To be really fair about this, there would likely be several series centered around various events/lore, leading to multiple main characters.
Bilgewater:
Shadow Isles:
Demacia:
Noxus:
Ionia:
Zaun:
Bandle City:
Piltover:

And that's just major areas, each of which could have varied interactions between the other ones.
it'd be based on the season. first it'd start with mordekaiser. then it'd go to garen. then it'd go back to karthus and yorick. then you'd see caitlyn and vi trying to take on jinx. yordles would never be main characters, but instead they'd be like sidekicks - think of happy from fairytale. the main character would always be a guy unless it was a perverted anime like 99.9% of funimation's animes. the main guy would always be a good guy or a bad guy who needs to tell his tale about turning evil - like anakin from starwars and how he turned into darth vader.
and 
It'd be dreadful regardless.