You should be able to use quickcast on some abilities and quickcast with indicator on others.
In the in-game options you can choose to set some abilities to normal cast and others to quickcast. For example, on lee sin you might typically use normal cast for most abilities but you could set your ward and w abilities to be quickcast for better ward hops. I always use quickcast with indicator, but for a few abilities (like ward hops on lee sin) I would prefer to have standard quickcast. Currently if you select qucikcast with indicator it forces all abilities that are quickcasted to have the indicator and there is no way for you to set some abilities to have the indicator and others to be standard quickcast. This would be a great little change in my opinion if you could select normal cast, quickcast, or quickcast with indicator for each ability separately.
qw and r you would want to be quick cast with indicator so you can better aim them and judge the distance. While e you would just want it to pop as soon as you pushed the button and not released it. It would work similar to toggling quick cast and click cast.