For Morde, start with
so that your entire bot lane gets healing, and go
into full AP. He got a rework, so he now gets full XP when he kills any minion. Play him with a tank support (
is a favorite) and dominate everything. Be sure to take dragon a lot, as well.
Who do you mean as Dr. Glock? GP and Fiora got really good reworks for them, and Darius and Garen also got little reworks that helped them a lot. WARNING: DARIUS'S Q IS NOW VERY SLOW. But he's really good at Pentas now, so that's something.
Kassadin got a "rework" that was basically an enormous nerf, and now he's absolutely terrible. He can't really do anything anymore, so never play him.