She can get stunned or silenced or interrupted and it still goes off. It removes a lot of Kassadin's ability to ever trade reliably, and shuts down champions with CC. Unlike seemingly every other champ in the game, her channel doesn't actually count as a channel, despite being functionally the same thing. I can't think of a champion that so greatly destroys the rules of the game in a similar way.
Infernape1 votesIt's just a long cast animation. The only way to cancel it is to kill her before it completes.
lil box1 votesCan't kill her before it completes because she can use 
during her ult to become untargetable
Still Virgiñ1 votesNeeko using Zhonyas during ult only works during the channel. And if she is using Zhonyas during the channel, you dove onto her. Either way, using it during the channel means she cannot move to position herself to hit her targets.
Zhonyas cannot be used after the first 1.25 seconds of the channel.
It can only be used during the channel, or after she lands.
