Going completely on your last ranked game where you played Vlad
Your rune page should be changed. You don't want just all Magic and Magic Pen for any champion. Runes play a HUGE impact early game and can help win or at least survive laning phase if it's a hard match up. I'd suggest doing MPen Marks, Armor Seals (yellows), MR Glyphs (blues), and AP Quints. If the enemy team is all AD (and no AP), you could switch out our Glyphs with more AP, MPen, or CD Reduction if you'd like.
For masteries, you have it right for 0/12/18 but right now Grasp of Undying is better, IMO in Top lane. I'd switch out Runic Affinity for either of the others...Secret Stash if you're just going to mainly farm and try to out farm them, or Assassin if you want to be a lane bully. Dangerous Game isn't worth taking on Vlad...he has no mana so half of that is getting unused. I'd take Bandit. You could do 6/6/18 too and put 5 in Sorcery, and 1 in Feast too. That would make you hurt a bit more, plus Feast would give you a bit more sustain.
Build wise, though I don't play Vlad much, looks good for him. You went Will first, then went Spirit Visage...though I don't know if Spirit Visage was that good of an item only because they had no AP champions on their team. Kind of a wasted stat.
You warded only 3 times total throughout the whole 33 minute game. Ideally, always put your trinkets down when they are available. Vision is key especially when you're losing lane, as you are more at risk for ganks.
It's hard to give any pointers in game because I can't watch the video, but I'd suggest recording your games just so you can rewatch them and see what mistakes were made. Ideally, as Vlad, you should dominate that match up against Nasus. You have the poke and massive sustain.
Also how the heck do you and your duo friend have the same name?! I'm obviously missing some part that's different from them.....