How is runeglaive on nasus?

No, I asked a Rioter on the forums and he told me that the Q is only consumed once. There's your answer.

If you for some reason had an all AD team AND went Nasus jungle it might be good as a cheesey "nobody is building MR so this won't have any resistances to go through". That's literally the only legit use I can think for it however.