I'm a one trick Vladimir and made it to Silver 5 with him. I hold a pretty solid winrate, 64% and played him around 300+ times already. I don't think he's a particularly difficult champion but definitely must be played "differently." He has high cooldowns early which means you must play safe until you hit level 8 - 9 and obtained some CDR. Generally, you don't want to harass your opponent before then and just worry about farming. Remember, your opponent has to rely on 2 resources: health and mana. You only need to focus on one. If your opponent burns out their mana, it's usually enough for them to recall which means you don't have to worry too much about harassing them.
For a combo that's guaranteed to kill your opponent at half health once you're level 9 I recommend:
Flash + Hextech Protobelt + R + Empowered Q + Charge E + W + E Release.
Mastering the W + E combo takes a bit of work so stick with:
Flash + Hextech Protobelt + R + Empowered Q + E + W, for now.
You can throw an ignite at the end if you want, but I think this combo should be enough to kill most champions that aren't too tanky: Galio, Cho'gath, etc.
. Tried some few games with him in ranked ( went from B3 to B2 with just him alone) a few games were me being carried or just me carrying the team. But the learning curve for Vladimir is so hard. So the point of this thread is to see if you guys can give me some combos that are vital to 
