Spell cast with mouse?

What?

Go into the hotleys and select a secondary button for each ability. Then use your mouses buttons for it. It also depends what kind of mouse you have...

Bind your abilities to different mouse buttons. You will likely need a mouse with extra buttons.

A mouse with extra buttons (i.e. left click, right click, then on the sides of the mouse 1 2 3 4 for abilities, 1234567 for items and such, maybe just a few for those ones, [what's needed...]) after that is done you just have to bind the right mouse buttons to the right places.

I watched him play with a PS4 controller the other day. It's all about key bindings. Most gaming mice have additional buttons, which you can bind to normal keyboard keys.

Guys I meant like in box box's video... where he got a penta by clicking the abilities in the hud, not shortcuts.

I found out that it's in the interface tab under Abilities....