I'm certainly not an Ori main, I find her way too hard, but I can give tips for runes and a small, simple tip that you can hide the Ball inside a wall. No idea what this is good for, but you can do it.
But for runes: I played on the PBE and toyed around with some theorycraft builds on the website before then, so here's an example rune page and a breakdown for it: http://na.leagueoflegends.com/en/featured/preseason-update/8200-8229?build=21222362
Arcane Comet does a lot of damage, and your Q W combo basically guarantees it'll hit because of the slow.
The Ultimate Hat is because you have a big ticket ultimate that can very well change a teamfight, but you can choose the other 2 as well. All 3 are really good, just depends on what you like. I personally like getting 60% ult CDR on anyone whose ult is extremely important.
Absolute Focus because the extra damage is nice, though if you want the CDR or Movement Speed one, they're also pretty good. Just whatever your preference is, but if you can stay safe enough, having 40 bonus AP is really good.
And finally Gathering Storm because in my opinion that's the only one in the last group worth running.
Inspiration secondary for that extra 5% CDR that puts your ult on a 60% reduced cooldown alongside Ultimate Hat and for Perfect Timing, because who doesn't like getting a 600 gold item that builds into a really good item for free?