What is the BEST possible team comp for Vayne?

Dont take my word for this, but i would go for maybe 1 or 2 tanks, another champion that can keep vayne in the teamfights (eg: Soraka), and if you wanna focus solely on Vayne, and someone who has a lot of cc(Kinda like Ashe, TF, etc) and utility(Karma, a lot of other supports, etc) in their kit.

The best teammates for Vayne

/ / / // / / / / / / //

I think the best possible comp for her would be

/ / /

Vayne would like a beefy frontline that draws a lot of attention from her - something like Maokai or Nautilus is perfect as they lock down a target for her for sit there and get Silver Bolts off. She also likes having someone to keep her moderately healthy (Soraka, Karma, Lulu, etc.) whether it be through shields or healing. Anything helps in her case, as Vayne-spotting is practically a sport to the enemy team. She's a terrifying force after a few items that can delete almost anyone with her raw damage within a few seconds. She's extremely vulnerable to CC and requires intense mechanical interaction with such a low cooldown Tumble in order to stay alive. She's very flashy and can easily clean up an entire team if they're out of position (check out some of Gosu's videos for inspiration, he certainly takes Vayne to her limits frequently, or old-school Piglet) much like a lot of other ADC's, however Vayne's Passive allows her to chase down otherwise safe targets much easier. She's very duelist-esque for an ADC.

Best possible team comp? Perhaps something similar to the Juggermaw setup (i.e. dump all your hopes and damage into Kog'Maw while he frontlines and protect him at all costs) with lots of shields and peel for her. Put a Lulu, Lee Sin, Nami/Janna, and Nautilus/Maokai together and watch Vayne do her magic. The only problem with this strategy is that is requires Vayne to position near-perfect all the time and it is VERY prone to flanks. If someone is able to melt the ADC before everyone can protect them, or if Lulu is forced to blow her Ultimate to save someone else it all falls apart quickly as the damage is virtually nonexistent.

Vayne fits decently into solo-queue as she is able to punish out of position individuals VERY hard and coordinated teamplay is much more difficult than with a trained team. She doesn't fit well into the competitive scene due to her incredibly short range compared to other ADCs and lacks early game lane presence - she's almost guaranteed to lose lane to anyone with poke/waveclear, as she has neither of these early game. That's generally why Ashe/Caitlyn/Varus/Jhin have seen so much competitive play - all of these ADCs bring the capability of being safe at extreme range while still providing utility. They all also bring the capability of initiating a fight (aside from Caitlyn, who makes up for her lack of initiation with by far some of the most difficult siege/anti-siege capability with her traps) which Vayne severely lacks - she would much rather clean up fights than start them herself (not including 1v1's, as she excels greatly with her extreme kiting/disengage and rather enjoys 3-shotting the cocky Ezreals [and other squishies] that stay in lane for those last minions).

Beefy champions. I played against a team that was all beef with a Vayne wiggling around in team fights. Impossible to beat. They keep her from being focused and she kills everything, both tanks and squishies with the same effort.

4 tanks

Because thats the best possible team comp for anything