Theory Crafting: No need for Mana regen items? + Early tank builds

If you pick Resolve Rune with Inspiration Sub rune: You get +150 health. Plus if you pick "Celestial Body" you get an additional 100 health. These would be perfect for any early tank builds or even support as they are more sustainable early game. This also means there would be no purpose to get dorans shield or ruby crystal early game. Also the inspiration rune "Mana flow band" Every 60 seconds your next ability gets its mana cost refunded plus you get back 8% of mana. Basically meaning you get a free ult attack every 60 seconds. This could mean you wouldn't need as many mana regen items and could focus your items on other things. I feel like this meta is going to play around with what items ppl are going to use depending on the runes they are using.

Thoughts? I barely started last week but having a new season is exciting.