Warwick seems a bit overbearing
Admittedly, I haven't played a bunch of games with/against him as the patch is pretty fresh, but I did see him on the PBE so it's not a total gut reaction.
Basically, he takes the Champion Smite and gets a hefty amount of true damage added onto his ult. If he gets well ahead and picks up a Wit's End or w/e, he's able to 100->0 non-tanks with a simple Smite->Ult. I can't imagine that his ult was ever intended to do something like that as there's nothing one can do about it except pal around with an ally who can interrupt.
I'm betting (hoping) what I've seen have been edge cases, but they've been very scary edge cases.