Negative Interaction with new Attack Move change
I like the new attack move change in that it targets the unit nearest your cursor, that's really helpful when trying to kite enemy champions in creep waves or chase one down, however, there's a fairly counter intuitive, negative interaction with this new setting that causes more harm than the benefit it gives.
When you attempt to attack an enemy champion with attack move using the "Target Champion Only" key bind with the new attack move change, previously you could just click near them and it would attack them, because you were using attack move, and the enemy champion was the only valid target. Now, doing that will result in attacking a minion near your cursor instead, even though it's not a valid target to be attacked. This is fairly annoying as, generally speaking, if you have to use Target Champion Only, that means they're standing dead center in a pile of creeps, making it more likely than not your cursor is going to be closer to a creep than a champion.