Rune Stats:
What are the Minimum statistic gains from runes that make an effective in game performance difference?
Im asking a very broad question that would require a wall of text to answer, but im not really able to figure this stuff out. If im looking at my rune page and I have a single Greater Mark of Damage at +0.95. At what point do the runes add up to make an actual difference? Where can I learn how to figure that out?