Mac Client Officially Unplayable (Can't Click)

I'm pretty sure this is exclusive to mac, but please correct if wrong.

For the past two days, clicking on summoner's rift is extremely unresponsive. I'd say every 5-10 clicks do not register. Sometimes it takes 5-10 clicks in the SAME SPOT to finally get it to register. You can forget about playing ADC with this issue, and it makes every other role extremely aggravating to play. I've never had a problem like this before, and I believe it came with the addition of the new Riven/Thresh skins.

Help!