issues with long cooldown abilities, ignite, trinkets and ultimates not not going off

I've noticed this a few times in game where I will try to ignite the enemy and it will not go off, it just acts as though no button was pushed, the other summoner spells seem to work fine, even exhaust which would have the same issue if it were an issue with targeting the enemy. I'm not certain if this is related to the cool down of the spell because in a recent game I hadn't used it yet and still experienced this problem. I was running the mastery that reduces the cool down of summoner spells by 10%, I think this may potentially be part of the issue but I'm not sure. I've also had a similar issue with champion ultimates that have just come off cool down recently, where you can push the button but nothing happens, they seem to be only ultimates that apply a buff to either an ally or your own champ, ex. Vayne, Kayle, Tryndamere, Riven, Taric; Kayles works on other champs but trying to self target is where the issue arises.

I've also had an issue with the yellow trinket going on cool down without having been used, or at least displaying that it is on cool down randomly after about 5-10 minutes into the game.