Minimap Targeting
When you play ashe and target the minimap with your E (hawkshot) it will instead target not that spot but bottom right corner of your current screen (if your minimap is bottom right.
(Ex. You are ashe on blue side and bottom lane. You wish to hawkshot their blue. you click that location on your minimap, instead you fire your hawkshot downward.)
P.S. I use quick cast, I have not tried this on normal cast.