Well, according to Jellbug during the AMA, Kayle and Morgana do have a part to play in Runeterra's future.
Their mother's sword falling from the skies was a major moment that denoted something dire happening on a large (Celestial) scale. Also, their mother was chosen as the Aspect of Justice in part because she was pregnant with Kayle and Morgana, who the Aspect knew would exemplify two different sides of justice. So yes, I do think they would have a part to play in Runeterra's salvation and in anything that happens in Targon prime.
I know that it's mostly what she thinks, and that as long as it's not on Universe it's not canon, but I do think she's right. If Mihira was partly chosen because she was pregnant with Kayle and Morgana, I doubt Targon wouldn't have any plans for them. Now, the fact that they don't have sentient godlike entities inside of them might make them more volatile (they are "harder to control", at least Morgana, since Kayle is big Targon fangirl). But I do think they'll have something to do against a great threat coming later (at the end of the Canticle, assuming it can be trusted as some sort of prophecy, a threat will rize and be accompanied by Kayle's return). It seems like the most logical course of action for them both.
Kayle & Morgana are less strong than Celestial Aspects because they don't literally have an immortal god in their heads. BUT if they fought together, their opposing beliefs in justice, punishment, and mercy PLUS their different magical abilities would make them much more than the sum of their parts.
I'd also like to point that out. While they are not as strong as your typical Hosts (I think it could be debatable depending on which Aspects, given they grow stronger as time goes by, and most of our Hosts (except Zoe) are relatively young, but I think she's speaking in a general), they would be really powerful if they were fighting together.
Kayle and Morgana definitely still have love for each other, even if it's buried under a lot of emotional baggage. If they were to meet again (which I think they should!) they both would need the humility to admit their mistakes. Perhaps this would happen if they encountered a common enemy...
And finally this. While this doesn't mean anything (and I'm probably reading too much into it), it sounds like some foreshadowing... Right? Well, let's assume it is (because, even if it's not, Jellbug's right. A common enemy would make them more akin to fight alongside each other), the question would be, what threat? Is it gonna be the Void again? Is it gonna be something else? How is it gonna play out?
I think Kayle and Morgana are interesting characters (even though I've seen many people think the contrary), my only real issue being that we don't know much about them in the present, and I doubt we're getting back to them anytime soon, so we'll probably have to wait for a long, long time... :(