Considering the Vastayashai'rei were pretty well in-tune with the spiritual world, and from what we know about the Oovi-Kat (the apparent closest descendants to the Vastayashai'rei in present-day Runeterra), one could probably assume that the Vastayashai'rei would have been more than okay - even pleased - with the union with humankind and resultant half-breeds.
On the human side, though, there would probably be mixed opinions about getting in with the Vastayashai'rei (starting to wish there was a halfway decent shorthand). Unless they were something like the pre-Noxus Ionians (one with nature/magic, pretty generous worldview) or the pre-Ruination Blessed Isles (wisened, good depth of knowledge, probably could see the benefit even if opposed), it's hard to imagine there wouldn't be a little conflict from humans regarding mixing with the Vastayashai'rei.
But, these are just my assumptions, so do take them with a mountain of salt.