Keys not binding properly?

I've been having this issue where when I load into the game my keys don't work, except the space bar. I've read psot about this before and a Riot employee said to first fully close LoL then go into League of Legends / Config on my computer and delete game.cfg and PersistedSetting.json then reconnect. While this used to work for me it stopped working for me today, once the game was over I joined a custom and had no issues.