[Possible Workaround] - New client tabbing out when you press MB5/MB4 in game? Try this...
I've seen it alot recently, and i experienced it myself. You are ingame, press your side buttons on your mouse and boom you're back to windows desktop and you lost a game. Very frustrating. So try this and let me know if this workaround solved the issue, while we wait for Riot to fix it...
1. Log In
2. Once the main client is open, go to task manager and close the process: "*RiotClientServices.exe 32" Don't use "Kill whole process tree".
3. No more problem in game and losing teamfights for pressing side buttons for the whole session.
** 4.** When/if you relog, you will have to repeat step 2.
Also if you find other fixes or have more knowledge about this, feel free to post here.