Mouse gets stuck to the middle of my screen after "Victory"/"Defeat"

I end up not being able to move my mouse it just gets stuck in the middle of my screen. This happens quite often and it only fixes itself when I restart my desktop after every game.

1. Only ever happens after the game ends
2. Can't click continue to exit out of the game after Victory or Defeat screen
3. Have to alt+ctrl+del and restart my computer
4. Only happens with League? When alt+ctrl+del I can use my mouse.

Looked everywhere for answers, couldn't find anything. Thanks!