Game Glitchitng

Recently I encountered a bug that seems a bit unusual. I was playing the game and at the start I press my auto-lock camera button (y) and it didn't work. I thought it was my key board, but that wasn't the case. I could type in chat just fine. This wasn't the only problem. Let's say I was playing , I use my E on a targeted person, but it doesn't go off. I have to click it multipel times for it to work and sometimes it doesn't work at all. When I place something down aswell (wards) it does the same thing likel with 's E. I tried reinstalling the game to see if it would fix the problem. For a few games it did, but it started acting up again. I am using the Mac version of League and if anyone knows how to fix this problem please let me know. Thank you.