Abilities flying in random directions
EDIT: Cause determined, fix now needed
It's back again. Happened multiple times as Morgana in a game a few minutes ago. I would have camera centered, aim near bottom of screen (may or may not have been over the HUD, but nowhere near minimap), toss a Q while mouse was DIRECTLY on top of them, and the Binding would throw itself out about 150 degrees clockwise from where I aimed.
Edit: I have figured it out the cause of this, during a game today as Lux. When you click on YOUR OWN champion's portrait, the one located to the left of your abilities, it attempts to cast it centered on yourself. This does one of two things, depending if you're moving or not. If you are stationary, it sometimes shoots directly OPPOSITE from wherever your mouse is from your champion, but always shoots in an upper-right direction. If you are moving, it casts it in the direction you were, so 180 degrees directly behind you.
Self-casting targeted abilities by clicking your own picture on your HUD should either not work at all, or only for abilities that can actually affect yourself (or have an options toggle, which I'm not aware of currently existing for this).