Keyboard messed up - Shortkeys not working

It has happend a couple of times to me now that keyboard get messed up

In the middle of the game the QWER shortkeys don't work, and the same with D and F

Sometimes it is posible to click the spell with your mouse but not always

I have tryed to go to settings -> keyboard -> set to default THIS DOES NOT FIX THE PROBLEM

Im running Windows 10 on my Lenovo Y50 and iv never had problems with LoL