Application was unable to start correctly. (Oxc0000022). Click OK to close the application

I keep getting this message. I can log in, go through Champ Select, and then when the loading screen should launch, the client crashes. It's been this way since the patch. I've reinstalled, run in compatibility mode, run hextech checker tool, enabled legacy components, etc. All to no avail. Now it's even a pain to test because I'm Leaver Bustered because of "being AFK" in games I've never even joined. Please advise, this is incredibly frustrating.