Annie and Zoe.

After watching the annie and Zoe origins video I think that riot might do something where both young girls run into each other and become friends with one another. Would be a really interesting concept because if Zoe becomes friends with Annie she would have some sort of human relationship to cherish and that would make the end of the world harder for Zoe to just passively watch happen instead of doing something. For Annie it might allow her witness a being who doesnt care too much about Annie's scary magic and would find adorable. Just think two extremely powerful and naive little girls running around runeterra would make for an entertaining story.