It would be awesome if League had a story mode/ playable campaigns.
After watching a video of Project Overcharge game play I feel like Leagues combat system could be made into a story mode. It could technically be Riots second game. It would still be set in Runeterra, it would still have league combat, and it could have us playing as our favorite champions in a Diablo 3 like campaign. I think that would be so fun and would be the perfect compliment to the universe they have set up.
Even when playing the Star Guardian game mode I felt like missions like that could be made into a League like left for dead game. Just expand it into full on story missions. One mission could be breaking out of the Zuan prison. One could be the climbing to the top of Mount Targon.
Your account could be shared between games and earning Blue Essence in all of them would be unlocking the same champions. Or maybe having Mastery 7 gets you the champ for free in the new games or something, there are so many different cool ways you could connect them.
Even something like final fantasy tactics/xcom would be cool. Runeterra lore is too good to never actually get to play in it.