You should be able to chose different v/o's for different champions
With Koyasu Takehito (Dio's voice actor) voice acting Sett in the Japanese client, and sounding better than the English version imo, i would so much rather hear the Japanese version of him than English, along with other champions like Yasuo and Zed. Personally, I think if it doesn't take too much effort to implement, you should be able to chose what language you hear for different things in game, such as different character voices and announcers. I think this would also be good for people who play in regions that dont allow you to play in your native language, such as playing on the Korean server and not being able to use English as the language, etc.