Kai'Sa's visual design isn't convincing enough
I see a lot of players have already expressed their concerns about Kai'Sa and her flat personality (which I personally think has healthy depth to it), but I'm here to talk about her visual character design.
Kai'Sa's "second skin" isn't much of a second skin. I don't think the Void creature is well-integrated with Kai'Sa herself. Frankly, it looks like she's wearing normal human armor. It's 100% possible that this is what the creation team was going for; maybe Kai'Sa tried to constantly remind herself she's human while she was stranded, maybe it was a coping mechanism -- this would make sense. Even so, Kai'Sa's second skin comes off as a weak design choice. If there were a little something more cluing me in on the fact that a Void creature is physically inseparable from her, if there were a more radical integration with this creature (heavily affecting her face possibly), it would feel less like a costume and more like an actual biological phenomenon.
Cassiopeia, although pretty humanoid, still manages to be creepy and it's obvious she's more monster than human. Nami, also humanoid, manages to read as an actual fish half the time (she doesn't have that cliche half-woman, half-fish, mix'n'match mermaid design). Their monster halves are well-integrated. Lissandra is an especially good example of this. Her proportions are excessively skewed to the point that you can easily tell she's corrupted and essentially a monster. They didn't need to add an extra limb to her to get the point across that she's not human. Meanwhile, Kai'Sa looks like Katarina in cosplay. Her physique is similar to that of every other human female in the game.
One way this could be fixed, and I've mentioned this briefly, is by some sort of transformation to Kai'Sa's head. Lissandra's bizarre head piece is a huge contributor to her disturbing design since we, as humans, generally assign just as much value to the appearance of the face/head as we do to the body. Likewise, Kai'Sa's body could very well stand to be changed. Something akin to Soraka's goat legs would be enough.
TL;DR: Kai'Sa looks like Katarina in cosplay and could use a more significant Void makeover. A small change to her decidedly human physique, along the lines of a limb exchange or having to do with how the resident Void creature clashes with her natural biological makeup, would keep her from looking like every other human female champ in the game.