Broken Keybindings? [Gameplay]

I'm not sure why, but at least a quarter of the time when I load into a game, my keybindings don't work. I can't cast skillshots, summoner spells, I can't do anything but move, auto-attack, and chat. In order to fix this issue, I have to quit the game and restart the client. Is this a known issue for people? Because I googled it and didn't see anything about it happening to others.