Can't Left Click in some games

In some games i cant left click at all. I am using a Mac laptop, with a Black dell mouse,t but i don't think thats the problem. I used the mouse playing league like from season 2. i never got the bug. Until i came back playing league ends of season 4. Now with the new Map update i have been getting theses bugs with my smurfs and main. This means i cant open shop unless i press p. if i press p i cant buy anything! and i cant select an ability at the start of the game. also i can move but my cam wont move its locked to spawn. and i pressed the key for it to lock on my champion but its frozen. This is huge for me because am getting lots of lots of leaver busters notice. also its just straight up annoying when i cant play at all. Pls help me it would mean a lot to me thx.