Unresponsive mouse/cursor?

I play a game, i even check my pings before going into ranked and everything is fine on my side. In the Game it occurs that i either dont move and cannot move at all or am auto attacking whatever enemy is near without the ability to stop it. I can see the Game proceeding and my allies and enemies moving around but i cant do anthing at all myself. I cant move, cant buy/sell, cant use abilities etc. ( btw my ping always stays 50m/s my FPS always stay at my capped 144)

It has cost me a few games and iv'e seen other people post about the same problem but no one ever seems to have a solution