SWAIN CANNOT USE KEYS-CLIENT/GAMEPLAY?!

Whenever I load into a game where I've selected Swain as my champion positioned in the bot lane, I am unable to use any of my keyboard keys in game such as abilities, camera control, pings, summoner spells, etc. I am however able to use the escape function. Changing quick-cast or the macros does not seem to resolve the problem, however, exiting the match and reconnecting has solved the issues every time.

1. I select Swain as my champ in the bot lane role.
2. Runes are comet, nimbus cloak, transcendence, gathering storm. Bone plating and chrysalis secondary.
3. Teleport and flash for summoners.
4. I load into game and am unable to lock or unlock camera or use my first selected ability.
5. I exit game and reconnect and the issue is resolved.

I've only played this twice, but it has occurred in both instances and is debilitating to the point where I felt necessary to make mention.