Cannot click anything in game!

Basically, I would load into a game and I cannot click anything. My left and right click inputs don't seem to register in the game. Everything on my keyboard works just fine (I can access shop with P and use summoners with D + F). I've tried restarting my client and reloading the game multiple times. This also happened during a ranked game, I'm trying to contact Riot Support, but the page isn't loading correctly for me. If anyone knows anything that may be helpful, please let me know. Thanks.

EDIT: Alright, this is not a permanent fix, but I manage to get it working again by restarting my whole system. I also did some research and a few people had this problem in the past as well. Not sure if it was ever addressed, but I hope Riot would address this issue so no one would have to go through this.