Mouse and keybord randomly stops working when fighting

Sometimes when i play, my mouse and keybord stops working randomly. It seems to be happening when im close to enemies. Im dying because i cant escape, when being chased, because i cant click. Its nothing wrong with the mouse or keybord. I try to click with my touchpad, but that doesnt work either. I go out of game, it works perfectly fine. Im on a macbook aswell.