Cleanse Bug
I played a Dynamic Queue game as Azir, and saw a Warwick and Lux on the enemy team, so I grabbed Cleanse. Cleanse is supposed to remove all disables whilst reducing incoming disables by 65%. What I got was the inability to cleanse a Warwick ult. I could not click it. I could not press the corresponding key, nothing worked. I just had there to sit and take the ulti on multiple occasions, which was rather detrimental to an otherwise winnable game. As the primary damage dealer on the team, it was going to be up to me to take at least 2-3 people out of each fight, and due to this cleanse not functioning correctly, I could not do so.
I had the Cleanse on the F key and flash on D. This happened about two times through the course of the game in situations where cleanse was available.