Abilities not working

So this has happened in my past 5 games. Every game I've played different champions and come across the same issue. I try to press a button to use an ability, and nothing goes off. I'm stuck auto attacking unless I spam the esc key, dc and reconnect, or if I just level up. Am I the only one experiencing this?

EDIT: I would also like to add this happened to me in draft norms and in ARAM.