Added video proof,cant click on minions or turrets or shop,cant cast spells on minions,happens in the random moment of the game (sometimes early,sometimes late).Lost much LP already because of that bug and im getting tired of it 
Any solution or help? Have anyone else occured this ? How did u repair it?
ProphetOfDraven1 votesMaybe you have target champions only on.
NotHereToCarry1 voteswhy & where does that turn on automatically? I mean in the middle of the game out of a random just cant hit anything anymore lol
ProphetOfDraven1 votesIf target champions only is actually the root of the problem then it's probably you hitting it's activation button by accident. By default its ` the grave key above tab.
NotHereToCarry1 votesi will try it in the next game and let you know asap. I have this symbol above tab though: ¸
NotHereToCarry1 votesjust happened again.... ` doesnt seem to help....