I've been having this really terrible glitch for a year or two now.

Basically at random (I assume through some sort of key, click, etc. sequence) my key board will do nothing as far as selecting abilities go, my left mouse button will still let me move around and my right mouse button will signal the 'get back' warning in-game if I try to click to focus anything. If I minimize game client, everything works fine--the only way to get rid of this if the game is still going if for me to CTRL+ALT+Delete and End Task the LoL client then his the 'reconnect' button and reload the game. I've reinstalled the game, I'm baffled at what the issue is frankly because my regular duo partner never experiences this glitch.

Do any wrenches or reds have any clue what's wrong?