Mouse crashing

Okay so I don't know why but a few months ago I started experiencing random crashes of my mouse whenever I play League, it doesn't happen in any other game I play. No matter what I do I can't seem to fix the problem, I've tried reinstalling league, reinstalling my mouse drivers, using a different mouse etc. but I can't fix the problem. It's borderline making the game unplayable, sometimes it won't happen for a while but other times it acts up and does it multiple times a game. It's ruined many games for me, I'll be winning my lane or be at an important point in the game and all of a sudden my mouse crashes and I walk off into a random direction more often then not directly into the enemy team with no control over my character. You can imagine what this causes to happen on my team, the amount of times I've been flamed for "intentionally feeding" is too high, I've been trying to limit my ranked games because I don't want to ruin my games but this happens with no predictability at all. It's really debilitating and I'd like a fix to the problem if anyone could offer one or has had a similar experience so at least I know I'm not the only one this is happening to. Thanks in advance.